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 Previous Article

J Virol. 1972 January; 9(1): 187-188
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Selective Inhibition of the Synthesis of Sindbis Virion Proteins by an Inhibitor of Chymotrypsin

E. R. Pfefferkorn and Mary K. Boyle

Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire 03755

ABSTRACT

Treatment of chick embryo fibroblasts infected with Sindbis virus with TPCK, the choloromethyl ketone derivative of tosyl-phenylalanine and an inhibitor of chymotrypsin, resulted in reduced synthesis of viral structural proteins and the accumulation of a high-molecular-weight polypeptide, thought to be a precursor. The analogous inhibitor of trypsin, TLCK, the chloromethyl ketone derivative of tosyllysine, had no such effect.

J Virol. 1972 January; 9(1): 187-188
Copyright © 1972 American Society for Microbiology. All Rights Reserved.





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