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J Virol. 1972 January; 9(1): 17-21
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Effect of Nalidixic Acid on the Growth of Deoxyribonucleic Acid Bacteriophages

Judith P. Baird, Gerard J. Bourguignon and Rolf Sternglanz

1 Department of Biochemistry, State University of New York, Stony Brook, New York 11790

ABSTRACT

The effect of nalidixic acid on the growth of various deoxyribonucleic acid (DNA) bacteriophages has been investigated by one-step growth experiments. The Escherichia coli bacteriophages T5, {lambda}, T7 and {varphi}R are strongly inhibited by nalidixic acid, whereas T4 and T2 are only partially inhibited. The Bacillus subtilis bacteriophages SP82, SP50, and {varphi}29 are relatively unaffected by nalidixic acid. There is no correlation between those bacteriophages which can grow in the presence of nalidixic acid and the presence of an unusual base in the phage DNA.

J Virol. 1972 January; 9(1): 17-21
Copyright © 1972 American Society for Microbiology. All Rights Reserved.



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Copyright © 1972 by the American Society for Microbiology. All rights reserved.