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J Virol. 1972 January; 9(1): 110-115
Copyright © 1972 American Society for Microbiology. All Rights Reserved.

Immunological Relationships of Reverse Transcriptases from Ribonucleic Acid Tumor Viruses

Wade P. Parks, Edward M. Scolnick, Jeffrey Ross, George J. Todaro and Stuart A. Aaronson

1 Viral Carcinogenesis Branch and Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland 20014

ABSTRACT

Antiserum to partially purified reverse transcriptase from the Schmidt-Ruppin strain of Rous sarcoma virus has been prepared and characterized. Antibody to the avian polymerase inhibited the reverse transcriptase activity of avian C-type viruses but had no effect on the polymerase activity from C-type viruses of other classes. The known mammalian C-type viral polymerases were significantly inhibited only by the antiserum to murine C-type viral polymerases; reverse transcriptases from four other mammalian viruses were immunologically distinct from both avian and mammalian C-type viral polymerases. Partially purified murine leukemia viral DNA polymerase activity was comparably reduced by specific antibody regardless of the template used for enzyme detection.

J Virol. 1972 January; 9(1): 110-115
Copyright © 1972 American Society for Microbiology. All Rights Reserved.



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Copyright © 1972 by the American Society for Microbiology. All rights reserved.