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Journal of Virology, April 2009, p. 3977-3981, Vol. 83, No. 8
0022-538X/09/$08.00+0     doi:10.1128/JVI.02400-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

The Infected Cell Protein 0 Encoded by Bovine Herpesvirus 1 (bICP0) Associates with Interferon Regulatory Factor 7 and Consequently Inhibits Beta Interferon Promoter Activity{triangledown}

Kazima Saira, You Zhou, and Clinton Jones*

Department of Veterinary and Biomedical Sciences, Nebraska Center for Virology, University of Nebraska, Lincoln, Nebraska 68503

Received 20 November 2008/ Accepted 19 January 2009

The bICP0 protein encoded by bovine herpesvirus 1 stimulates productive infection and viral gene expression but inhibits interferon (IFN)-dependent transcription. bICP0 inhibits beta IFN (IFN-β) promoter activity and induces degradation of IFN regulatory factor 3 (IRF3). Although bICP0 inhibits the trans-activation activity of IRF7, IRF7 protein levels are not reduced. In this study, we demonstrate that bICP0 is associated with IRF7. Furthermore, bICP0 inhibits the ability of IRF7 to trans-activate the IFN-β promoter in the absence of IRF3 expression. The interaction between bICP0 and IRF7 correlates with reduced trans-activation of the IFN-β promoter by IRF7.

* Corresponding author. Mailing address: Department of Veterinary and Biomedical Sciences, Nebraska Center for Virology, University of Nebraska, Lincoln, NE 68503. Phone: (402) 472-1890. Fax: (402) 472-9690. E-mail: cjones{at}unlnotes.unl.edu

{triangledown} Published ahead of print on 28 January 2009.

Journal of Virology, April 2009, p. 3977-3981, Vol. 83, No. 8
0022-538X/09/$08.00+0     doi:10.1128/JVI.02400-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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