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Journal of Virology, April 2009, p. 3413-3416, Vol. 83, No. 7
0022-538X/09/$08.00+0     doi:10.1128/JVI.02419-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Discovery of Herpes B Virus-Encoded MicroRNAs{triangledown}

Michael I. Besecker,1 Mallory E. Harden,1 Guanglin Li,2 Xiu-Jie Wang,2 and Anthony Griffiths1*

Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas,1 State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People's Republic of China2

Received 24 November 2008/ Accepted 5 January 2009

Herpes B virus (BV) naturally infects macaque monkeys and is a close relative of herpes simplex virus. BV can zoonotically infect humans to cause a rapidly ascending encephalitis with ~80% mortality. Therefore, BV is a serious danger to those who come into contact with these monkeys or their tissues and cells. MicroRNAs are regulators of gene expression, and there have been reports of virus-encoded microRNAs. We hypothesize that BV-encoded microRNAs are important for the regulation of viral and cellular genes. Herein, we report the discovery of three herpes B virus-encoded microRNAs.

* Corresponding author. Mailing address: Dept. of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, TX 78227. Phone: (210) 258-9557. Fax: (210) 670-3329. E-mail: agriffiths{at}sfbr.org

{triangledown} Published ahead of print on 14 January 2009.

Journal of Virology, April 2009, p. 3413-3416, Vol. 83, No. 7
0022-538X/09/$08.00+0     doi:10.1128/JVI.02419-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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