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Journal of Virology, April 2009, p. 3379-3383, Vol. 83, No. 7
0022-538X/09/$08.00+0     doi:10.1128/JVI.02529-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Identification of Potential Recombination Breakpoints in Human Parechoviruses{triangledown}

Jan Zoll,* Jochem M. D. Galama, and Frank J. M. van Kuppeveld

Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands

Received 9 December 2008/ Accepted 14 January 2009

Based on a comparison of the phylogeny of two distant regions, evidence has been found for recombination within parechoviruses. However, recombination breakpoints could not be detected in this way. We searched for potential recombination breakpoints in parechovirus by analysis of complete parechovirus sequences, including a newly isolated strain. Bootscan analysis demonstrated that parechoviruses are mosaic viruses build of regions related to corresponding genomic regions of other parechoviruses. With a genetic algorithm for recombination detection, sites for recombination were found. Analysis of partial sequences, as defined by recombination breakpoints, showed phylogenetic segregation between regions.

* Corresponding author. Mailing address: Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Phone: (31) 24 3617574. Fax: (31) 24 3614666. E-mail: j.zoll{at}ncmls.ru.nl

{triangledown} Published ahead of print on 28 January 2009.

Journal of Virology, April 2009, p. 3379-3383, Vol. 83, No. 7
0022-538X/09/$08.00+0     doi:10.1128/JVI.02529-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Williams, C. H., Panayiotou, M., Girling, G. D., Peard, C. I., Oikarinen, S., Hyoty, H., Stanway, G. (2009). Evolution and conservation in human parechovirus genomes. J. Gen. Virol. 90: 1702-1712 [Abstract] [Full Text]  


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