This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vatakis, D. N.
Right arrow Articles by Zack, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vatakis, D. N.
Right arrow Articles by Zack, J. A.

 Previous Article  |  Next Article 

Journal of Virology, April 2009, p. 3374-3378, Vol. 83, No. 7
0022-538X/09/$08.00+0     doi:10.1128/JVI.02161-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Differentially Stimulated CD4+ T Cells Display Altered Human Immunodeficiency Virus Infection Kinetics: Implications for the Efficacy of Antiviral Agents{triangledown}

Dimitrios N. Vatakis,1,3 Christopher C. Nixon,2 Gregory Bristol,1,3 and Jerome A. Zack1,2,3*

David Geffen School of Medicine at UCLA, Department of Medicine, Division of Hematology/Oncology,1 Department of Microbiology Immunology and Molecular Genetics,2 UCLA AIDS Institute, Los Angeles, California 900953

Received 13 October 2008/ Accepted 2 January 2009

The activation state of CD4+ T cells plays a crucial role in the establishment of a productive human immunodeficiency virus infection. Here, we show that T cells stimulated for 1 day demonstrated delayed kinetics of viral reverse transcription and integration compared to cells stimulated for 2 days prior to infection. As a result, the efficiency of reverse transcription and integration inhibitors differs in these differentially stimulated cells. These studies increase our understanding of how T cells support viral replication and provide insight regarding the efficiency of antiretroviral therapy in lymphoid compartments.

* Corresponding author. Mailing address: 615 Charles E. Young Drive South, BSRB 173 Mailcode: 736322, Los Angeles, CA 90095. Phone: (310) 825-0876. Fax: (310) 983-1067. E-mail: jzack{at}ucla.edu

{triangledown} Published ahead of print on 7 January 2009.

Journal of Virology, April 2009, p. 3374-3378, Vol. 83, No. 7
0022-538X/09/$08.00+0     doi:10.1128/JVI.02161-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Arfi, V., Lienard, J., Nguyen, X.-N., Berger, G., Rigal, D., Darlix, J.-L., Cimarelli, A. (2009). Characterization of the Behavior of Functional Viral Genomes during the Early Steps of Human Immunodeficiency Virus Type 1 Infection. J. Virol. 83: 7524-7535 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»