This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Peloponese, J.-M.
Right arrow Articles by Jeang, K.-T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Peloponese, J.-M., Jr.
Right arrow Articles by Jeang, K.-T.

 Previous Article  |  Next Article 

Journal of Virology, April 2009, p. 3238-3248, Vol. 83, No. 7
0022-538X/09/$08.00+0     doi:10.1128/JVI.01824-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Peptidylproline cis-trans-Isomerase Pin1 Interacts with Human T-Cell Leukemia Virus Type 1 Tax and Modulates Its Activation of NF-{kappa}B{triangledown}

Jean-Marie Peloponese Jr.,1,2,3* Junichiro Yasunaga,1 Takao Kinjo,1 Koichi Watashi,1 and Kuan-Teh Jeang1

Molecular Virology Section, Laboratory of Molecular, Microbiology, the National Institute of Allergy and Infectious Diseases, the National Institutes of Health, Bethesda, Maryland 20892-0460,1 Université Montpellier 1 and CNRS, UM5236, Centre d'Études d'Agents Pathogènes et Biotechnologies pour la Santé, Montpellier F-34965, France,2 Université Montpellier 2, Centre d'Études d'Agents Pathogènes et Biotechnologies pour la Santé, Montpellier F-34095, France3

Received 29 August 2008/ Accepted 14 January 2009

Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus etiologically causal of adult T-cell leukemia (ATL). The virus encodes a Tax oncoprotein that functions in transcriptional regulation, cell cycle control, and transformation. ATL is a highly virulent cancer that is resistant to chemotherapeutic treatments. To understand this disease better, it is important to comprehend how HTLV-1 promotes cellular growth and survival. Tax activation of NF-{kappa}B is important for the proliferation and transformation of virus-infected cells. We show here that prolyl isomerase Pin1 is over expressed in HTLV-1 cell lines; Pin1 binds Tax and regulates Tax-induced NF-{kappa}B activation.

* Corresponding author. Mailing address: Université Montpellier 1 and CNRS, UM5236, Centre d'Études d'Agents Pathogènes et Biotechnologies pour la Santé, Montpellier F-34965, France. Phone: 33 467 600 349. Fax: 33 467 604 420. E-mail: jean-marie.peloponese{at}univ-montp1.fr

{triangledown} Published ahead of print on 21 January 2009.

Journal of Virology, April 2009, p. 3238-3248, Vol. 83, No. 7
0022-538X/09/$08.00+0     doi:10.1128/JVI.01824-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»