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 Previous Article

Journal of Virology, March 2009, p. 2789-2794, Vol. 83, No. 6
0022-538X/09/$08.00+0     doi:10.1128/JVI.02191-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Sindbis Virus-Based Measles DNA Vaccines Protect Cotton Rats against Respiratory Measles: Relevance of Antibodies, Mucosal and Systemic Antibody-Secreting Cells, Memory B Cells, and Th1-Type Cytokines as Correlates of Immunity {triangledown}

Marcela F. Pasetti,1,2* Karina Ramirez,1,2 Aldo Resendiz-Albor,1,2 Jeffrey Ulmer,4 Eileen M. Barry,1,3 and Myron M. Levine1,2,3

Center for Vaccine Development,1 Departments of Pediatrics,2 Medicine, University of Maryland School of Medicine, 685 West Baltimore St., Room 480, Baltimore, Maryland 21201,3 Novartis Vaccines and Diagnostics, 4650 Horton Street, Emeryville, California 946084

Received 16 October 2008/ Accepted 28 December 2008

Measles remains an important cause of pediatric morbidity and mortality in developing countries, especially among infants who are too young to receive the current licensed live attenuated measles vaccine. We developed two Sindbis virus DNA vaccines encoding the measles virus hemagglutinin (pMSIN-H) and fusion proteins (pMSINH-FdU) and examined their immunogenicities and protective efficacies when administered alone or followed by the live measles virus vaccine in cotton rats. Neutralizing antibodies, mucosal and systemic antibody-secreting cells, memory B cells, and gamma interferon-secreting T cells developed after priming and increased after boosting. pMSIN-H priming conferred 100% protection against pulmonary measles, whereas pMSINH-FdU protected only in conjunction with the live measles virus vaccine boost.

* Corresponding author. Mailing address: Center for Vaccine Development, University of Maryland, 685 W. Baltimore St., Room 480, Baltimore, MD 21201. Phone: (410) 706 2341. Fax: (410) 706 6205. E-mail: mpasetti{at}medicine.umaryland.edu

{triangledown} Published ahead of print on 7 January 2009.

Journal of Virology, March 2009, p. 2789-2794, Vol. 83, No. 6
0022-538X/09/$08.00+0     doi:10.1128/JVI.02191-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Carsillo, M., Klapproth, K., Niewiesk, S. (2009). Cytokine Imbalance after Measles Virus Infection Has No Correlation with Immune Suppression. J. Virol. 83: 7244-7251 [Abstract] [Full Text]  


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