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Journal of Virology, March 2009, p. 2778-2782, Vol. 83, No. 6
0022-538X/09/$08.00+0     doi:10.1128/JVI.01420-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Efficient Replication of Human Immunodeficiency Virus Type 1 in Resting CD4+ T Lymphocytes Is Induced by Coculture with Autologous Dendritic Cells in the Absence of Foreign Antigens{triangledown}

Corinne Barat,1,3 Caroline Gilbert,2,3 and Michel J. Tremblay1,3*

Centre de Recherche en Infectiologie,1 Centre de Recherche en Rhumatologie et Immunologie,2 Centre Hospitalier de l'Université Laval, and Département de Biologie Médicale, Faculté de Médecine, Université Laval, Québec, Canada3

Received 8 July 2008/ Accepted 19 December 2008

Dendritic cells (DC) are considered to be important contributors to human immunodeficiency virus type 1 (HIV-1) transmission and pathogenesis. As the first target cells in mucosal tissues, they can be become productively infected and can also capture virions and transfer them efficiently to CD4+ T cells located within lymphoid tissues. Resting CD4+ T cells appear to be another major target of HIV-1 in vivo, yet several blocks restrict replication in such cells. We report here that physical contact between virus-infected quiescent CD4+ T cells and uninfected autologous immature DC in the absence of any foreign antigen relieves these restrictions, allowing a highly productive HIV-1 replication.

* Corresponding author. Mailing address: Laboratoire d'Immuno-Rétrovirologie Humaine, Centre de Recherche en Infectiologie, RC709, 2705 Boul. Laurier, Québec (QC), Canada G1V 4G2. Phone: (418) 654-2705. Fax: (418) 654-2212. E-mail: michel.j.tremblay{at}crchul.ulaval.ca

{triangledown} Published ahead of print on 24 December 2008.

Journal of Virology, March 2009, p. 2778-2782, Vol. 83, No. 6
0022-538X/09/$08.00+0     doi:10.1128/JVI.01420-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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