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Journal of Virology, March 2009, p. 2386-2388, Vol. 83, No. 5
0022-538X/09/$08.00+0     doi:10.1128/JVI.01116-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Sharing of Endogenous Lentiviral Gene Fragments among Leporid Lineages Separated for More than 12 Million Years{triangledown}

W. van der Loo,1,2* J. Abrantes,1,2 and P. J. Esteves1,3

Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade do Porto, Porto, Portugal,1 Departamento de Zoologia e Antropologia da Faculdade de Ciências da Universidade do Porto, Porto, Portugal,2 Centro de Investigação em Tecnologias da Saúde, IPSN, CESPU, Gandra, Portugal3

Received 27 May 2008/ Accepted 5 December 2008

Lentiviruses are causal agents of severe pathologies of a variety of mammals, including cattle and humans (e.g., AIDS and different types of lymphoma). While endogenous forms of lentivirus do not occur in these species, A. Katzourakis and coworkers (A. Katzourakis, M. Tristem, O. G. Pybus, and R. J. Gifford, Proc. Natl. Acad. Sci. USA 104:6261-6265, 2007) recently reported the presence in the genome of the European rabbit (Oryctolagus cuniculus) of multiple sequences defining a lentiviral subgroup elegantly referred to as RELIK (rabbit endogenous lentivirus type K). Sequence comparisons indicated that the RELIK ancestor may have integrated into the rabbit lineage more than 7 million years ago. We have substantiated this by producing sequence data certifying the sharing of RELIK sequences among leporid lineages that diverged some 12 million years ago.

* Corresponding author. Mailing address: Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade do Porto, Campus Agrario de Vairao, 4485-661 Vairao, Portugal. Phone: 351 252 660 400. Fax: 351 252 661 780. E-mail: wvdloo{at}mail.icav.up.pt

{triangledown} Published ahead of print on 24 December 2008.

Journal of Virology, March 2009, p. 2386-2388, Vol. 83, No. 5
0022-538X/09/$08.00+0     doi:10.1128/JVI.01116-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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