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Journal of Virology, March 2009, p. 2382-2385, Vol. 83, No. 5
0022-538X/09/$08.00+0     doi:10.1128/JVI.01607-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Inhibition of Lassa and Marburg Virus Production by Tetherin{triangledown}

Toshie Sakuma,1 Takeshi Noda,2 Shuzo Urata,1 Yoshihiro Kawaoka,2,3 and Jiro Yasuda1*

First Department of Forensic Science, National Research Institute of Police Science, Kashiwa 277-0882, Japan,1 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan,2 Department of Pathological Sciences, School of Veterinary Medicine, University of Wisconsin—Madison, Madison, Wisconsin 537063

Received 29 July 2008/ Accepted 2 December 2008

Recently, tetherin has been identified as an effective cellular factor that prevents the release of human immunodeficiency virus type 1. Here, we show that the production of virus-like particles induced by viral matrix proteins of Lassa virus or Marburg virus was markedly inhibited by tetherin and that N-linked glycosylation of tetherin was dispensable for this antiviral activity. Our data also suggest that viral matrix proteins or one or more components that originate from host cells are targets of tetherin but that viral surface glycoproteins are not. These results suggest that tetherin inhibits the release of a wide variety of enveloped viruses from host cells by a common mechanism.

* Corresponding author. Mailing address: First Department of Forensic Science, National Research Institute of Police Science, 6-3-1 Kashiwanoha, Kashiwa 277-0882, Japan. Phone: 81-4-7135-8001. Fax: 81-4-7133-9159. E-mail: yasuda{at}nrips.go.jp

{triangledown} Published ahead of print on 17 December 2008.

Journal of Virology, March 2009, p. 2382-2385, Vol. 83, No. 5
0022-538X/09/$08.00+0     doi:10.1128/JVI.01607-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



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