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Journal of Virology, February 2009, p. 1532-1537, Vol. 83, No. 3
0022-538X/09/$08.00+0     doi:10.1128/JVI.01937-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Recombinant Canine Coronaviruses Related to Transmissible Gastroenteritis Virus of Swine Are Circulating in Dogs{triangledown}

Nicola Decaro,1* Viviana Mari,1 Marco Campolo,1 Alessio Lorusso,1 Michele Camero,1 Gabriella Elia,1 Vito Martella,1 Paolo Cordioli,2 Luis Enjuanes,3 and Canio Buonavoglia1

Department of Public Health and Animal Sciences, Faculty of Veterinary Medicine, Valenzano (Bari), Italy,1 Istituto Zooprofilattico Sperimentale di Lombardia ed Emilia Romagna, via A. Bianchi 9, 25124 Brescia, Italy,2 Centro Nacional de Biotecnologia, Department of Molecular and Cell Biology, Campus Universidad Autonoma, Cantoblanco (Madrid), Spain3

Received 15 September 2008/ Accepted 17 November 2008

Four canine coronavirus type II (CCoV-II) strains were identified in the guts and internal organs of pups which had died of acute gastroenteritis. The CCoV-II strains were strictly related to porcine transmissible gastroenteritis virus (TGEV) in the N-terminal domain of the spike protein, whereas in the other parts of the genome, a higher genetic relatedness to recent CCoV-II isolates was observed. Experimental infection of dogs with a TGEV-like isolate induced mild gastroenteritis without any systemic involvement. By virus neutralization tests, antigenic differences between reference and TGEV-like CCoVs were found. Our data support the potential recombinant origin of the TGEV-like CCoVs.

* Corresponding author. Mailing address: Department of Public Health and Animal Sciences, Faculty of Veterinary Medicine of Bari, Strada per Casamassima km 3, 70010 Valenzano, Bari, Italy. Phone: 390804679832. Fax: 390804679843. E-mail: n.decaro{at}veterinaria.uniba.it

{triangledown} Published ahead of print on 26 November 2008.

Journal of Virology, February 2009, p. 1532-1537, Vol. 83, No. 3
0022-538X/09/$08.00+0     doi:10.1128/JVI.01937-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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