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Journal of Virology, November 2009, p. 11996-12001, Vol. 83, No. 22
0022-538X/09/$08.00+0     doi:10.1128/JVI.00791-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

A Highly Attenuated Measles Virus Vaccine Strain Encodes a Fully Functional C Protein{triangledown}

Yuichiro Nakatsu,§ Makoto Takeda,§* Masaharu Iwasaki, and Yusuke Yanagi

Department of Virology, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

Received 20 April 2009/ Accepted 20 August 2009

The P, V, and C proteins of measles virus are encoded in overlapping reading frames of the P gene, which makes it difficult to analyze the functions of the individual proteins in the context of virus infection. We established a system to analyze the C protein independently from the P and V proteins by placing its gene in an additional transcription unit between the H and L genes. Analyses with this system indicated that a highly attenuated Edmonston lineage vaccine strain encodes a fully functional C protein, and the P and/or V protein is involved in the attenuated phenotype.

* Corresponding author. Mailing address: Department of Virology, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Phone: 81-92-642-6138. Fax: 81-92-642-6140. E-mail: mtakeda{at}nih.go.jp

{triangledown} Published ahead of print on 2 September 2009.

§ Present address: National Institute of Infectious Diseases, Musashimurayama, Tokyo 208-0011, Japan.

Journal of Virology, November 2009, p. 11996-12001, Vol. 83, No. 22
0022-538X/09/$08.00+0     doi:10.1128/JVI.00791-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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