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Journal of Virology, November 2009, p. 11979-11982, Vol. 83, No. 22
0022-538X/09/$08.00+0     doi:10.1128/JVI.01847-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Chloroquine Administration Does Not Prevent Nipah Virus Infection and Disease in Ferrets{triangledown} ,{dagger}

Jackie Pallister,1* Deborah Middleton,1 Gary Crameri,1 Manabu Yamada,1 Reuben Klein,1 Tim J. Hancock,1 Adam Foord,1 Brian Shiell,1 Wojtek Michalski,1 Christopher C. Broder,2 and Lin-Fa Wang1

CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria 3220, Australia,1 Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland 208142

Received 31 August 2009/ Accepted 3 September 2009

Hendra virus and Nipah virus, two zoonotic paramyxoviruses in the genus Henipavirus, have recently emerged and continue to cause sporadic disease outbreaks in humans and animals. Mortality rates of up to 75% have been reported in humans, but there are presently no clinically licensed therapeutics for treating henipavirus-induced disease. A recent report indicated that chloroquine, used in malaria therapy for over 70 years, prevented infection with Nipah virus in vitro. Chloroquine was assessed using a ferret model of lethal Nipah virus infection and found to be ineffective against Nipah virus infection in vivo.

* Corresponding author. Mailing address: CSIRO Livestock Industries, 5 Portarlington Road, Geelong, Victoria 3220, Australia. Phone: 61 3 5227 5205. Fax: 61 3 5227 5555. E-mail: jackie.pallister{at}csiro.au

{triangledown} Published ahead of print on 16 September 2009.

{dagger} The authors have paid a fee to allow immediate free access to this article.

Journal of Virology, November 2009, p. 11979-11982, Vol. 83, No. 22
0022-538X/09/$08.00+0     doi:10.1128/JVI.01847-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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