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Journal of Virology, November 2009, p. 11397-11401, Vol. 83, No. 21
0022-538X/09/$08.00+0     doi:10.1128/JVI.00989-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Murine Gammaherpesvirus 68 Infection of Gamma Interferon-Deficient Mice on a BALB/c Background Results in Acute Lethal Pneumonia That Is Dependent on Specific Viral Genes{triangledown}

Katherine S. Lee,1,{dagger} Carlyne D. Cool,3,4,{dagger} and Linda F. van Dyk1,2,{dagger}*

Departments of Microbiology,1 Immunology,2 Pathology, University of Colorado Denver, School of Medicine, Aurora, Colorado,3 National Jewish Health, Denver, Colorado4

Received 15 May 2009/ Accepted 19 August 2009

Gamma interferon (IFN-{gamma}) is critical for the control of chronic infection with murine gammaherpesvirus 68 ({gamma}HV68). Current data indicate that IFN-{gamma} has a lesser role in the control of acute replication of {gamma}HV68. Here, we show that IFN-{gamma}-deficient mice on the BALB/c genetic background poorly control acute viral replication and succumb to early death by acute pneumonia. Notably, this acute, lethal pneumonia was dependent not only on the viral dose, but also on specific viral genes including the viral cyclin gene, previously identified to be important in promoting optimal chronic infection and reactivation from latency.

* Corresponding author. Mailing address: University of Colorado School of Medicine, Departments of Microbiology and Immunology, Mail Stop 8333, 12800 E. 19th Ave., P.O. Box 6511, Aurora, CO 80045. Phone: (303) 724-4207. Fax: (303) 724-4226. E-mail: linda.vandyk{at}ucdenver.edu

{triangledown} Published ahead of print on 26 August 2009.

{dagger} Contributions: K.S.L. performed research; C.D.C. analyzed histological tissues; and K.S.L. and L.F.V.D. designed experiments, interpreted data, and wrote the manuscript.

Journal of Virology, November 2009, p. 11397-11401, Vol. 83, No. 21
0022-538X/09/$08.00+0     doi:10.1128/JVI.00989-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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