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Journal of Virology, November 2009, p. 10975-10980, Vol. 83, No. 21
0022-538X/09/$08.00+0     doi:10.1128/JVI.00273-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Analysis of Nucleotide Sequences of Human Parvovirus B19 Genome Reveals Two Different Modes of Evolution, a Gradual Alteration and a Sudden Replacement: a Retrospective Study in Sapporo, Japan, from 1980 to 2008{triangledown}

Masashi Suzuki, Yuko Yoto,* Aki Ishikawa, and Hiroyuki Tsutsumi

Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Japan

Received 6 February 2009/ Accepted 14 August 2009

There have been no long-term systematic analyses of the molecular epidemiology of human parvovirus B19 (B19V). We investigated the variations of nucleotide sequences of B19V strains collected in Sapporo, Japan, from 1980 to 2008. In that period, six outbreaks of erythema infectiosum occurred regularly at 5-year intervals. The B19V strains collected successively, regardless of the outbreak, were analyzed for nucleotide variation in the subgenomic NS1-VP1u junction. The isolated strains can be classified into 10 subgroups. Two patterns of change of endemic strains were observed. One was a dynamic replacement of strains that occurred almost every 10 years, and the other was a gradual change consisting of an accumulation of point mutations.

* Corresponding author. Mailing address: Department of Pediatrics, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo 060-8543, Japan. Phone: 81-11-611-2111. Fax: 81-11-611-0352. E-mail: yoto{at}sapmed.ac.jp

{triangledown} Published ahead of print on 26 August 2009.

Journal of Virology, November 2009, p. 10975-10980, Vol. 83, No. 21
0022-538X/09/$08.00+0     doi:10.1128/JVI.00273-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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