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Journal of Virology, October 2009, p. 10840-10843, Vol. 83, No. 20
0022-538X/09/$08.00+0     doi:10.1128/JVI.01202-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

T-Cell Vaccination Reduces Simian Immunodeficiency Virus Levels in Semen{triangledown}

James B. Whitney,1 Corinne Luedemann,1 Peter Hraber,2 Srinivas S. Rao,3 John R. Mascola,3 Gary J. Nabel,3 and Norman L. Letvin1,3*

Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115,1 Los Alamos National Laboratory, Los Alamos, New Mexico 87545,2 Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 208923

Received 11 June 2009/ Accepted 22 July 2009

Recent findings suggest that most sexual transmission of human immunodeficiency virus type 1 (HIV-1) occurs during the acute phase of infection when viral replication is most intense. Here, we show that vaccine-elicited cellular immune responses can significantly reduce simian immunodeficiency virus levels in the semen during the period of primary infection in monkeys. A vaccine that decreases the quantity of HIV-1 in the semen of males during primary infection might decrease HIV-1 transmission in human populations and therefore affect the spread of AIDS.

* Corresponding author. Mailing address: Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, CLS 1043, 3 Blackfan Circle, Boston, MA 02215. Phone: (617) 735-4400. Fax: (617) 735-4527. E-mail: nletvin{at}bidmc.harvard.edu

{triangledown} Published ahead of print on 29 July 2009.

Journal of Virology, October 2009, p. 10840-10843, Vol. 83, No. 20
0022-538X/09/$08.00+0     doi:10.1128/JVI.01202-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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