This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Weissenborn, S. J.
Right arrow Articles by Pfister, H. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Weissenborn, S. J.
Right arrow Articles by Pfister, H. J.

 Previous Article  |  Next Article 

Journal of Virology, January 2009, p. 811-816, Vol. 83, No. 2
0022-538X/09/$08.00+0     doi:10.1128/JVI.01338-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Intrafamilial Transmission and Family-Specific Spectra of Cutaneous Betapapillomaviruses{triangledown}

S. J. Weissenborn,1* M. N. C. De Koning,2 U. Wieland,1 W. G. V. Quint,2 and H. J. Pfister1

Institute of Virology, University of Cologne, Fuerst-Pueckler-Str. 56, 50935 Cologne, Germany,1 DDL Diagnostic Laboratory, Voorburg, The Netherlands2

Received 26 June 2008/ Accepted 29 October 2008

Cutaneous human betapapillomaviruses (beta-HPVs) are widespread in the general population and have been associated with skin cancer. To evaluate the impact of continuous person-to-person contact within families on an individual's beta-HPV type spectrum, we collected serial skin swab samples from parents and children from 10 families. All participants were found to be beta-HPV DNA positive, with 1 to 13 types at study entry (median, 4.0 types). Initial and cumulative (2 to 16 types) HPV type multiplicities varied widely between different families but only a little between family members. The high intrafamilial correlation of HPV multiplicity is already obvious for babies aged 10 days to 10 months. Family members typically displayed similar spectra of HPV types. More than 75% of the HPV types in babies were also detected in their parents. This indicates that HPV transmission mainly results from close contact between family members. Type-specific persistence for at least 9 months was more prevalent in parents (92%) than in children (66%). Of the types detected throughout the study, 24% turned out to persist in the parents and only 11% in the children. Interestingly, about one-half of the HPV types found to persist in one of the parents occurred less frequently or even only sporadically in the spouse. Similarly, only one-third of the persisting parental types also persisted in their children. This indicates that even regular exposure to cutaneous HPV does not necessarily lead to the establishment of a persistent infection, which may point to type-specific susceptibilities of different individuals.

* Corresponding author. Mailing address: Institute of Virology, University of Cologne, Fuerst-Pueckler-Str. 56, 50935 Cologne, Germany. Phone: 49 221 4783911. Fax: 49 221 4783904. E-mail: Soenke.Weissenborn{at}uk-koeln.de

{triangledown} Published ahead of print on 5 November 2008.

Journal of Virology, January 2009, p. 811-816, Vol. 83, No. 2
0022-538X/09/$08.00+0     doi:10.1128/JVI.01338-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Marcuzzi, G. P., Hufbauer, M., Kasper, H. U., Weissenborn, S. J., Smola, S., Pfister, H. (2009). Spontaneous tumour development in human papillomavirus type 8 E6 transgenic mice and rapid induction by UV-light exposure and wounding. J. Gen. Virol. 90: 2855-2864 [Abstract] [Full Text]  
  • Li, L., Barry, P., Yeh, E., Glaser, C., Schnurr, D., Delwart, E. (2009). Identification of a novel human gammapapillomavirus species. J. Gen. Virol. 90: 2413-2417 [Abstract] [Full Text]  
  • Waterboer, T., Neale, R., Michael, K. M., Sehr, P., de Koning, M. N. C., Weissenborn, S. J., Sampogna, F., Abeni, D., Green, A. C., Bouwes Bavinck, J. N., Pawlita, M., the EPI-HPV-UV-CA Group, (2009). Antibody responses to 26 skin human papillomavirus types in the Netherlands, Italy and Australia. J. Gen. Virol. 90: 1986-1998 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»