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Journal of Virology, October 2009, p. 10293-10298, Vol. 83, No. 19
0022-538X/09/$08.00+0     doi:10.1128/JVI.01143-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Immune Evasion Proteins Enhance Cytomegalovirus Latency in the Lungs{triangledown}

Verena Böhm, Christof K. Seckert, Christian O. Simon, Doris Thomas, Angélique Renzaho, Dorothea Gendig, Rafaela Holtappels, and Matthias J. Reddehase*

Institute for Virology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany

Received 4 June 2009/ Accepted 7 July 2009

CD8 T cells control cytomegalovirus (CMV) infection in bone marrow transplantation recipients and persist in latently infected lungs as effector memory cells for continuous sensing of reactivated viral gene expression. Here we have addressed the question of whether viral immunoevasins, glycoproteins that specifically interfere with antigen presentation to CD8 T cells, have an impact on viral latency in the murine model. The data show that deletion of immunoevasin genes in murine CMV accelerates the clearance of productive infection during hematopoietic reconstitution and leads to a reduced latent viral genome load, reduced latency-associated viral transcription, and a lower incidence of recurrence in lung explants.

* Corresponding author. Mailing address: Institute for Virology, University Medical Center of the Johannes Gutenberg University, Hochhaus am Augustusplatz, 55131 Mainz, Germany. Phone: 49-6131-39-33651. Fax: 49-6131-39-35604. E-mail: Matthias.Reddehase{at}uni-mainz.de

{triangledown} Published ahead of print on 15 July 2009.

Journal of Virology, October 2009, p. 10293-10298, Vol. 83, No. 19
0022-538X/09/$08.00+0     doi:10.1128/JVI.01143-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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