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Journal of Virology, October 2009, p. 10280-10285, Vol. 83, No. 19
0022-538X/09/$08.00+0     doi:10.1128/JVI.00138-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Novel Translation Products from Simian Immunodeficiency Virus SIVmac239 Env-Encoding mRNA Contain both Rev and Cryptic T-Cell Epitopes{triangledown}

Nicholas J. Maness,* Jonah B. Sacha, Shari M. Piaskowski, Kimberly L. Weisgrau, Eva G. Rakasz, Gemma E. May, Matthew B. Buechler, Andrew D. Walsh, Nancy A. Wilson, and David I. Watkins

Department of Pathology and Laboratory Medicine, University of Wisconsin—Madison, Madison, Wisconsin 53706

Received 21 January 2009/ Accepted 2 July 2009

Understanding the correlates of immune protection against human immunodeficiency virus and simian immunodeficiency virus (SIV) will require defining the entire cellular immune response against the viruses. Here, we define two novel translation products from the SIV env mRNA that are targeted by the T-cell response in SIV-infected rhesus macaques. The shorter product is a subset of the larger product, which contains both the first exon of the Rev protein and a translated portion of the rev intron. Our data suggest that the translation of viral alternate reading frames may be an important source of T-cell epitopes, including epitopes normally derived from functional proteins.

* Corresponding author. Mailing address: Department of Pathology and Laboratory Medicine, University of Wisconsin—Madison, 555 Science Drive, Madison, WI 53711. Phone: (608) 890-0844. Fax: (608) 265-8084. E-mail: njmaness{at}wisc.edu

{triangledown} Published ahead of print on 15 July 2009.

Journal of Virology, October 2009, p. 10280-10285, Vol. 83, No. 19
0022-538X/09/$08.00+0     doi:10.1128/JVI.00138-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Maness, N. J., Wilson, N. A., Reed, J. S., Piaskowski, S. M., Sacha, J. B., Walsh, A. D., Thoryk, E., Heidecker, G. J., Citron, M. P., Liang, X., Bett, A. J., Casimiro, D. R., Watkins, D. I. (2010). Robust, Vaccine-Induced CD8+ T Lymphocyte Response against an Out-of-Frame Epitope. J. Immunol. 184: 67-72 [Abstract] [Full Text]  


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