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Journal of Virology, October 2009, p. 10269-10274, Vol. 83, No. 19
0022-538X/09/$08.00+0     doi:10.1128/JVI.01149-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Breadth of Neutralizing Antibody Response to Human Immunodeficiency Virus Type 1 Is Affected by Factors Early in Infection but Does Not Influence Disease Progression{triangledown}

Anne Piantadosi,1 Dana Panteleeff,1 Catherine A. Blish,1,3 Jared M. Baeten,2,3 Walter Jaoko,5 R. Scott McClelland,3,4,5 and Julie Overbaugh1*

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington,1 Departments of Global Health,2 Medicine,3 Epidemiology, University of Washington, Seattle, Washington,4 Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya5

Received 5 June 2009/ Accepted 21 July 2009

The determinants of a broad neutralizing antibody (NAb) response and its effect on human immunodeficiency virus type 1 (HIV-1) disease progression are not well defined, partly because most prior studies of a broad NAb response were cross-sectional. We examined correlates of NAb response breadth among 70 HIV-infected, antiretroviral-naïve Kenyan women from a longitudinal seroincident cohort. NAb response breadth was measured 5 years after infection against five subtype A viruses and one subtype B virus. Greater NAb response breadth was associated with a higher viral load set point and greater HIV-1 env diversity early in infection. However, greater NAb response breadth was not associated with a delayed time to a CD4+ T-cell count of <200, antiretroviral therapy, or death. Thus, a broad NAb response results from a high level of antigenic stimulation early in infection, which likely accounts for prior observations that greater NAb response breadth is associated with a higher viral load later in infection.

* Corresponding author. Mailing address: Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., C3-168, Seattle, WA 98109-1024. Phone: (206) 667-3524. Fax: (206) 667-1535. E-mail: joverbau{at}fhcrc.org

{triangledown} Published ahead of print on 29 July 2009.

Journal of Virology, October 2009, p. 10269-10274, Vol. 83, No. 19
0022-538X/09/$08.00+0     doi:10.1128/JVI.01149-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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