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Journal of Virology, September 2009, p. 9611-9615, Vol. 83, No. 18
0022-538X/09/$08.00+0     doi:10.1128/JVI.00936-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

The Efficacy of Antigen Processing Is Critical for Protection against Cytomegalovirus Disease in the Presence of Viral Immune Evasion Proteins{triangledown}

Rafaela Holtappels, Doris Thomas, and Matthias J. Reddehase*

Institute for Virology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany

Received 12 May 2009/ Accepted 19 June 2009

Cytomegaloviruses (CMVs) code for immunoevasins, glycoproteins that are specifically dedicated to interfere with the presentation of antigenic peptides to CD8 T cells. Nonetheless, the biological outcome is not an immune evasion of the virus, since CD8 T cells can control CMV infection even when immunoevasins are expressed. Here, we compare the processing of a protective and a nonprotective epitope derived from the same viral protein, the antiapoptotic protein M45 in the murine model. The data provide evidence to conclude that protection against CMVs critically depends on antigenic peptides generated in an amount sufficient to exhaust the inhibitory capacity of immunoevasins.

* Corresponding author. Mailing address: Institute for Virology, University Medical Center of the Johannes Gutenberg University, Hochhaus am Augustusplatz, 55131 Mainz, Germany. Phone: 49-6131-39-3651. Fax: 49-6131-39-35604. E-mail: Matthias.Reddehase{at}uni-mainz.de

{triangledown} Published ahead of print on 4 June 2009.

Journal of Virology, September 2009, p. 9611-9615, Vol. 83, No. 18
0022-538X/09/$08.00+0     doi:10.1128/JVI.00936-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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