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Journal of Virology, September 2009, p. 9608-9610, Vol. 83, No. 18
0022-538X/09/$08.00+0     doi:10.1128/JVI.01127-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Prion Infectivity in Fat of Deer with Chronic Wasting Disease{triangledown}

Brent Race,# Kimberly Meade-White,# Richard Race, and Bruce Chesebro*

Rocky Mountain Laboratories, 903 South 4th Street, Hamilton, Montana 59840

Received 2 June 2009/ Accepted 24 June 2009

Chronic wasting disease (CWD) is a neurodegenerative prion disease of cervids. Some animal prion diseases, such as bovine spongiform encephalopathy, can infect humans; however, human susceptibility to CWD is unknown. In ruminants, prion infectivity is found in central nervous system and lymphoid tissues, with smaller amounts in intestine and muscle. In mice, prion infectivity was recently detected in fat. Since ruminant fat is consumed by humans and fed to animals, we determined infectivity titers in fat from two CWD-infected deer. Deer fat devoid of muscle contained low levels of CWD infectivity and might be a risk factor for prion infection of other species.

* Corresponding author. Mailing address: Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, 903 South Fourth St., Hamilton, MT 59840. Phone: (406) 363-9354. Fax: (406) 363-9286. E-mail: bchesebro{at}niaid.nih.gov

{triangledown} Published ahead of print on 1 July 2009.

# Shared first authorship.

Journal of Virology, September 2009, p. 9608-9610, Vol. 83, No. 18
0022-538X/09/$08.00+0     doi:10.1128/JVI.01127-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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