This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Reynard, O.
Right arrow Articles by Volchkov, V. E.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reynard, O.
Right arrow Articles by Volchkov, V. E.

 Previous Article  |  Next Article 

Journal of Virology, September 2009, p. 9596-9601, Vol. 83, No. 18
0022-538X/09/$08.00+0     doi:10.1128/JVI.00784-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Ebolavirus Glycoprotein GP Masks both Its Own Epitopes and the Presence of Cellular Surface Proteins{triangledown}

Olivier Reynard, Malgorzata Borowiak, Valentina A. Volchkova, Sebastien Delpeut, Mathieu Mateo, and Viktor E. Volchkov*

INSERM, U758, Laboratoire des Filovirus, Lyon F-69007, France; Université de Lyon, Lyon, F-69007, France; and Université Lyon 1, Lyon F-69007, France; and IFR 128 BioSciences Gerland-Lyon Sud, Lyon F-69007, France

Received 17 April 2009/ Accepted 25 June 2009

Ebolavirus (EBOV) is the etiological agent of a severe hemorrhagic fever with a high mortality rate. The spike glycoprotein (GP) is believed to be one of the major determinants of virus pathogenicity. In this study, we demonstrated the molecular mechanism responsible for the downregulation of surface markers caused by EBOV GP expression. We showed that expression of mature GP on the plasma membrane results in the masking of cellular surface proteins, including major histocompatibility complex class I. Overexpression of GP also results in the masking of certain antigenic epitopes on GP itself, causing an illusory effect of disappearance from the plasma membrane.

* Corresponding author. Mailing address: Laboratoire des Filovirus/INSERM U758, 21 Av. Tony Garnier, 69365 Lyon Cedex07, France. Phone: 33 437 282450. Fax: 33 437 282459. E-mail: viktor.volchkov{at}inserm.fr

{triangledown} Published ahead of print on 8 July 2009.

Journal of Virology, September 2009, p. 9596-9601, Vol. 83, No. 18
0022-538X/09/$08.00+0     doi:10.1128/JVI.00784-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»