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Journal of Virology, September 2009, p. 9008-9012, Vol. 83, No. 17
0022-538X/09/$08.00+0     doi:10.1128/JVI.00410-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Vaccinia Virus CD8+ T-Cell Dominance Hierarchies Cannot Be Altered by Prior Immunization with Individual Peptides{triangledown}

Yang Wang, Inge E. A. Flesch, and David C. Tscharke*

Department of Biochemistry & Molecular Biology, Research School of Biology, College of Medicine, Biology and the Environment, Australian National University, Canberra, ACT, Australia

Received 25 February 2009/ Accepted 4 June 2009

Heterologous prime-boost is a common vaccination strategy to elicit CD8+ T cells (TCD8+), and vaccinia virus (VACV) has been widely used as a boosting vector. Studies with other viruses have suggested that priming may reduce responses to native epitopes in boosting vectors as well as improve responses to primed epitopes. We explored this possibility with a VACV model in mice and find that irrespective of an epitope's dominance, prior priming was able to double TCD8+ responses. More surprisingly, and in contrast to findings for other viruses, responses to remaining epitopes were undisturbed, leaving the overall dominance hierarchy unchanged.

* Corresponding author. Mailing address: Department of Biochemistry and Molecular Biology, School of Biology, Australian National University, Canberra ACT 0200, Australia. Phone: 61 2 6125 3020. Fax: 61 2 6125 0313. E-mail: David.Tscharke{at}anu.edu.au

{triangledown} Published ahead of print on 17 June 2009.

Journal of Virology, September 2009, p. 9008-9012, Vol. 83, No. 17
0022-538X/09/$08.00+0     doi:10.1128/JVI.00410-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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