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Journal of Virology, September 2009, p. 8980-8985, Vol. 83, No. 17
0022-538X/09/$08.00+0     doi:10.1128/JVI.00786-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Computational Analysis of Human Adenovirus Type 22 Provides Evidence for Recombination among Species D Human Adenoviruses in the Penton Base Gene {triangledown}

Christopher M. Robinson,1 Jaya Rajaiya,1 Michael P. Walsh,2 Donald Seto,2 David W. Dyer,3 Morris S. Jones,4 and James Chodosh1*

Department of Ophthalmology, Howe Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts,1 Department of Bioinformatics and Computational Biology, George Mason University, Manassas, Virginia,2 Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma,3 Clinical Investigation Facility, David Grant USAF Medical Center, Travis, California4

Received 17 April 2009/ Accepted 18 June 2009

Recombination in human adenoviruses (HAdV) may confer virulence upon an otherwise nonvirulent strain. The genome sequence of species D HAdV type 22 (HAdV-D22) revealed evidence for recombination with HAdV-D19 and HAdV-D37 within the capsid penton base gene. Bootscan analysis demonstrated that recombination sites within the penton base gene frame the coding sequences for the two external hypervariable loops in the protein. A similar pattern of recombination was evident within other HAdV-D types but not other HAdV species. Further study of recombination among HAdVs is needed to better predict possible recombination events among wild-type viruses and adenoviral gene therapy vectors.

* Corresponding author. Mailing address: Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114. Phone: (617) 573-6398. Fax: (617) 573-4324. E-mail: james_chodosh{at}meei.harvard.edu

{triangledown} Published ahead of print on 24 June 2009.

Journal of Virology, September 2009, p. 8980-8985, Vol. 83, No. 17
0022-538X/09/$08.00+0     doi:10.1128/JVI.00786-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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