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Journal of Virology, September 2009, p. 8965-8969, Vol. 83, No. 17
0022-538X/09/$08.00+0     doi:10.1128/JVI.00606-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Phage Display Selection of Cyclic Peptides That Inhibit Andes Virus Infection{triangledown}

Pamela R. Hall,{dagger} Brian Hjelle, Hadya Njus, Chunyan Ye, Virginie Bondu-Hawkins, David C. Brown, Kathleen A. Kilpatrick, and Richard S. Larson*

Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131

Received 24 March 2009/ Accepted 5 June 2009

Specific therapy is not available for hantavirus cardiopulmonary syndrome caused by Andes virus (ANDV). Peptides capable of blocking ANDV infection in vitro were identified using antibodies against ANDV surface glycoproteins Gn and Gc to competitively elute a cyclic nonapeptide-bearing phage display library from purified ANDV particles. Phage was examined for ANDV infection inhibition in vitro, and nonapeptides were synthesized based on the most-potent phage sequences. Three peptides showed levels of viral inhibition which were significantly increased by combination treatment with anti-Gn- and anti-Gc-targeting peptides. These peptides will be valuable tools for further development of both peptide and nonpeptide therapeutic agents.

* Corresponding author. Mailing address: UNM School of Medicine, 2325 Camino de Salud, CRF 223, Albuquerque, NM 87131. Phone: (505) 272-6950. Fax: (505) 272-8738. E-mail: RLarson{at}salud.unm.edu

{triangledown} Published ahead of print on 10 June 2009.

{dagger} Present address: Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131.

Journal of Virology, September 2009, p. 8965-8969, Vol. 83, No. 17
0022-538X/09/$08.00+0     doi:10.1128/JVI.00606-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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