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Journal of Virology, August 2009, p. 8282-8288, Vol. 83, No. 16
0022-538X/09/$08.00+0     doi:10.1128/JVI.00235-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Intrathecal Humoral Responses Are Inversely Associated with the Frequency of Simian Immunodeficiency Virus Macrophage-Tropic Variants in the Central Nervous System{triangledown}

Elena Ryzhova,1 Pyone Aye,2 Tom Harvey,1 Wei Cao,1 Andrew Lackner,2 and Francisco González-Scarano1*

Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania,1 Tulane National Primate Research Center, Tulane University Health Science Center, New Orleans, Louisiana2

Received 3 February 2009/ Accepted 21 May 2009

Sustained simian immunodeficiency virus (SIV) infection of the central nervous system (CNS) depends on macrophage-tropic (M-tropic) strains that are often easily neutralizable. The CNS is often thought of as an immunologically privileged site that fosters replication of M-tropic quasispecies. Yet, there are limited data addressing the intrathecal antibody response or the role of the humoral response, in general, to control M-tropic strains. We investigated the temporal course of the intrathecal fusion inhibitory activity against an M-tropic viral variant and found an inverse relationship between the magnitude of this neutralization and the prevalence of M-tropic populations. These studies suggest a role for the humoral response in the suppression of M-tropic viral species in the CNS in experimental SIV infection.

* Corresponding author. Mailing address: Department of Neurology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104-4283. Phone: (215) 662-3360. Fax: (215) 662-3362. E-mail: scarano{at}mail.med.upenn.edu

{triangledown} Published ahead of print on 3 June 2009.

Journal of Virology, August 2009, p. 8282-8288, Vol. 83, No. 16
0022-538X/09/$08.00+0     doi:10.1128/JVI.00235-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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