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Journal of Virology, July 2009, p. 6429-6434, Vol. 83, No. 13
0022-538X/09/$08.00+0     doi:10.1128/JVI.00293-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

RuvB-Like Protein 2 Is a Suppressor of Influenza A Virus Polymerases{triangledown}

Satoshi Kakugawa,1 Masayuki Shimojima,1 Gabriele Neumann,2 Hideo Goto,1 and Yoshihiro Kawaoka1,2,3,4*

Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokaneda, Minato-ku, Tokyo 108-8639, Japan,1 Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, Wisconsin 53706,2 Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan,3 International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan4

Received 10 February 2009/ Accepted 6 April 2009

In pro- and eukaryotic cells, RuvB-like protein 2 (RBL2) resolves Holliday junction recombination intermediates. Here, we identified RBL2 as a suppressor of influenza A virus replication. Human RBL2 appears to interfere with the oligomerization of the viral nucleoprotein, a critical step in the assembly of viral replication complexes.

* Corresponding author. Mailing address: International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan. Phone: 81 3 5449 5310. Fax: 81 3 5449 5408. E-mail: kawaoka{at}ims.u-tokyo.ac.jp

{triangledown} Published ahead of print on 15 April 2009.

Journal of Virology, July 2009, p. 6429-6434, Vol. 83, No. 13
0022-538X/09/$08.00+0     doi:10.1128/JVI.00293-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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