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Journal of Virology, June 2009, p. 6318-6322, Vol. 83, No. 12
0022-538X/09/$08.00+0     doi:10.1128/JVI.00384-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Replication-Defective Adenovirus Vectors with Multiple Deletions Do Not Induce Measurable Vector-Specific T Cells in Human Trials{triangledown}

Richard A. Koup,1,2* Laurie Lamoreaux,2 David Zarkowsky,2 Robert T. Bailer,2 C. Richter King,3 Jason G. D. Gall,3 Douglas E. Brough,3 Barney S. Graham,4 and Mario Roederer5

Immunology Laboratory,1 Immunology Core Section,2 Clinical Trials Core,4 ImmunoTechnology Section, Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland,5 GenVec, Inc., Gaithersburg, Maryland3

Received 20 February 2009/ Accepted 25 March 2009

The magnitude and character of adenovirus serotype 5 (Ad5)-specific T cells were determined in volunteers with and without preexisting neutralizing antibodies (NAs) to Ad5 who received replication-defective Ad5 (rAd5)-based human immunodeficiency virus vaccines. There was no correlation between T-cell responses and NAs to Ad5. There was no increase in magnitude or activation state of Ad5-specific CD4+ T cells at time points where antibodies to Ad5 and T-cell responses to the recombinant gene products could be measured. These data indicate that rAd5-based vaccines containing deletions in the E1, E3, and E4 regions do not induce appreciable expansion of vector-specific CD4+ T cells.

* Corresponding author. Mailing address: Vaccine Research Center, NIAID, NIH, 40 Convent Drive, MSC 3022, Building 40, Room 3502, Bethesda, MD 20892. Phone: (301) 594-8574. Fax: (301) 480-2779. E-mail: rkoup{at}mail.nih.gov

{triangledown} Published ahead of print on 1 April 2009.

Journal of Virology, June 2009, p. 6318-6322, Vol. 83, No. 12
0022-538X/09/$08.00+0     doi:10.1128/JVI.00384-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Sun, Y., Bailer, R. T., Rao, S. S., Mascola, J. R., Nabel, G. J., Koup, R. A., Letvin, N. L. (2009). Systemic and Mucosal T-Lymphocyte Activation Induced by Recombinant Adenovirus Vaccines in Rhesus Monkeys. J. Virol. 83: 10596-10604 [Abstract] [Full Text]  


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