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Journal of Virology, June 2009, p. 6312-6317, Vol. 83, No. 12
0022-538X/09/$08.00+0     doi:10.1128/JVI.01671-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Characterization of the Interaction between Latency-Associated Nuclear Antigen and Glycogen Synthase Kinase 3β{triangledown}

Thilo Hagen*

Department of Biochemistry, National University of Singapore, Singapore 117597

Received 6 August 2008/ Accepted 17 March 2009

The latency-associated nuclear antigen (LANA) of Karposi's sarcoma-associated herpesvirus has been reported to interact with glycogen synthase kinase 3β (GSK-3β) and regulate its activity, leading to inhibition of GSK-3-dependent β-catenin degradation. In this study, the interaction between LANA and GSK-3β was characterized further. LANA was found to interact with GSK-3β in vitro as well as in intact cells. However, LANA did not regulate GSK-3β kinase activity and LANA-induced upregulation of β-catenin was GSK-3β independent. LANA did not regulate the stability of β-catenin or of its reported interaction partners p53 and von Hippel-Lindau protein. Additional targets of LANA are likely to mediate its malignancy-promoting function.

* Mailing address: Department of Biochemistry, National University of Singapore, Singapore 117597. Phone: (65) 65163686. Fax: (65) 67791453. E-mail: bchth{at}nus.edu.sg

{triangledown} Published ahead of print on 25 March 2009.

Journal of Virology, June 2009, p. 6312-6317, Vol. 83, No. 12
0022-538X/09/$08.00+0     doi:10.1128/JVI.01671-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.





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