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Journal of Virology, June 2009, p. 5951-5955, Vol. 83, No. 11
0022-538X/09/$08.00+0     doi:10.1128/JVI.00171-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Aquareovirus Effects Syncytiogenesis by Using a Novel Member of the FAST Protein Family Translated from a Noncanonical Translation Start Site{triangledown}

Trina Racine,1,{dagger} Tara Hurst,1,{dagger} Chris Barry,1 Jingyun Shou,1 Frederick Kibenge,3 and Roy Duncan1,2*

Department of Microbiology and Immunology,1 Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada B3H1X5,2 Department of Pathology and Microbiology, University of Prince Edward Island, Prince Edward Island, Canada C1A 4P33

Received 25 January 2009/ Accepted 10 March 2009

As nonenveloped viruses, the aquareoviruses and orthoreoviruses are unusual in their ability to induce cell-cell fusion and syncytium formation. While an extraordinary family of fusion-associated small transmembrane (FAST) proteins is responsible for orthoreovirus syncytiogenesis, the basis for aquareovirus-induced syncytiogenesis is unknown. We now report that the S7 genome segment of an Atlantic salmon reovirus is polycistronic and uses a noncanonical CUG translation start codon to produce a 22-kDa integral membrane protein responsible for syncytiogenesis. The aquareovirus p22 protein represents a fourth distinct member of the FAST family with a unique repertoire and arrangement of structural motifs.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5. Phone: (902) 494-6770. Fax: (902) 494-5125. E-mail: roy.duncan{at}dal.ca

{triangledown} Published ahead of print on 18 March 2009.

{dagger} These two authors contributed equally to this study.

Journal of Virology, June 2009, p. 5951-5955, Vol. 83, No. 11
0022-538X/09/$08.00+0     doi:10.1128/JVI.00171-09
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Barry, C., Duncan, R. (2009). Multifaceted Sequence-Dependent and -Independent Roles for Reovirus FAST Protein Cytoplasmic Tails in Fusion Pore Formation and Syncytiogenesis. J. Virol. 83: 12185-12195 [Abstract] [Full Text]  


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