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 Previous Article

Journal of Virology, January 2009, p. 489-492, Vol. 83, No. 1
0022-538X/09/$08.00+0     doi:10.1128/JVI.01166-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

A Functional MicroRNA-155 Ortholog Encoded by the Oncogenic Marek's Disease Virus{triangledown} ,{dagger}

Yuguang Zhao,1 Yongxiu Yao,1 Hongtao Xu,1 Luke Lambeth,1 Lorraine P. Smith,1 Lydia Kgosana,1 Xiaowei Wang,2 and Venugopal Nair1*

Viral Oncogenesis Group, Division of Microbiology, Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom,1 Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri 631102

Received 4 June 2008/ Accepted 13 October 2008

Kaposi's sarcoma-associated herpesvirus-encoded microRNA (miRNA) MiR-K12-11 was recently shown to be a functional ortholog of miR-155, a miRNA that plays a major role in lymphoid malignancies and the modulation of immune responses. Here we show that miR-M4, encoded by the highly oncogenic Marek's disease virus of chickens, shares common targets with miR-155 and thus is also a functional ortholog of miR-155, the first one identified in an alphaherpesvirus. The observation that two distinct oncogenic herpesviruses associated with distinct types of lymphomas in different species encode functional miR-155 orthologs suggested the importance of this miRNA in regulatory pathways and the biology of lymphomagenesis.

* Corresponding author. Mailing address: Viral Oncogenesis Group, Division of Microbiology, Institute for Animal Health, Compton, Berkshire RG20 7NN, United Kingdom. Phone: 441635 577356. Fax: 441635 577263. E-mail: venu.gopal{at}bbsrc.ac.uk

{triangledown} Published ahead of print on 22 October 2008.

{dagger} Supplemental material for this article may be found at http://jvi.asm.org/.

Journal of Virology, January 2009, p. 489-492, Vol. 83, No. 1
0022-538X/09/$08.00+0     doi:10.1128/JVI.01166-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Yao, Y., Zhao, Y., Smith, L. P., Lawrie, C. H., Saunders, N. J., Watson, M., Nair, V. (2009). Differential expression of microRNAs in Marek's disease virus-transformed T-lymphoma cell lines. J. Gen. Virol. 90: 1551-1559 [Abstract] [Full Text]  
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