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Journal of Virology, January 2009, p. 428-439, Vol. 83, No. 1
0022-538X/09/$08.00+0     doi:10.1128/JVI.01725-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.

Full-Length Genome Characterization of a Novel Simian Immunodeficiency Virus Lineage (SIVolc) from Olive Colobus (Procolobus verus) and New SIVwrcPbb Strains from Western Red Colobus (Piliocolobus badius badius) from the Taï Forest in Ivory Coast{triangledown}

Florian Liégeois,1 Bénédicte Lafay,2,{dagger} Pierre Formenty,3 Sabrina Locatelli,1 Valérie Courgnaud,1,{ddagger} Eric Delaporte,1 and Martine Peeters1*

UMR 145, Institut de Recherche pour le Developpement (IRD), and University of Montpellier 1, Montpellier, France,1 UMR CNRS-IRD 2724, Montpellier, France,2 Department of Epidemic and Pandemic Alert and Response, World Health Organization, Geneva, Switzerland3

Received 14 August 2008/ Accepted 3 October 2008

Simian immunodeficiency viruses (SIVs) are found in an extensive number of African primates and humans continue to be exposed to these viruses by hunting and handling of primate bushmeat. Full-length genome sequences were obtained from SIVs derived from two Colobinae species inhabiting the Taï forest, Ivory Coast, each belonging to a different genus: SIVwrc from western red colobus (Piliocolobus badius badius) (SIVwrcPbb-98CI04 and SIVwrcPbb-97CI14) and SIVolc (SIVolc-97CI12) from olive colobus (Procolobus verus). Phylogenetic analysis showed that western red colobus are the natural hosts of SIVwrc, and SIVolc is also a distinct species-specific lineage, although distantly related to the SIVwrc lineage across the entire length of its genome. Overall, both SIVwrc and SIVolc, are also distantly related to the SIVlho/sun lineage across the whole genome. Similar to the group of SIVs (SIVsyk, SIVdeb, SIVden, SIVgsn, SIVmus, and SIVmon) infecting members of the Cercopithecus genus, SIVs derived from western red and olive colobus, L'Hoest and suntailed monkeys, and SIVmnd-1 from mandrills form a second group of viruses that cluster consistently together in phylogenetic trees. Interestingly, the divergent SIVcol lineage, from mantled guerezas (Colobus guereza) in Cameroon, is also closely related to SIVwrc, SIVolc, and the SIVlho/sun lineage in the 5' part of Pol. Overall, these results suggest an ancestral link between these different lentiviruses and highlight once more the complexity of the natural history and evolution of primate lentiviruses.

* Corresponding author. Mailing address: UMR 145, Institut de Recherche pour le Développement, 911, Avenue Agropolis, 34394 Montpellier, France. Phone: (33) 0467416297. Fax: (33) 0467416146. E-mail: martine.peeters{at}mpl.ird.fr

{triangledown} Published ahead of print on 15 October 2008.

{dagger} Present address: Environmental Microbial Genomics Group, UMR CNRS 5005/EC-INSA-UCBL, Ecole Centrale de Lyon, Ecully, France.

{ddagger} Present address: Institut de Génétique Moléculaire de Montpellier, CNRS UMR5535, Université Montpellier 1 et 2, Montpellier, France.

Journal of Virology, January 2009, p. 428-439, Vol. 83, No. 1
0022-538X/09/$08.00+0     doi:10.1128/JVI.01725-08
Copyright © 2009, American Society for Microbiology. All Rights Reserved.



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