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Journal of Virology, May 2008, p. 4665-4670, Vol. 82, No. 9
0022-538X/08/$08.00+0     doi:10.1128/JVI.02403-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

The Ezrin-Radixin-Moesin Family Member Ezrin Regulates Stable Microtubule Formation and Retroviral Infection{triangledown}

Juliane Haedicke,1 Kenia de los Santos,2 Stephen P. Goff,2 and Mojgan H. Naghavi1,2*

Centre for Research in Infectious Diseases, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland,1 Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, Columbia University, New York, New York 100322

Received 7 November 2007/ Accepted 19 February 2008

We recently identified the cytoskeletal regulatory protein moesin as a novel gene that inhibits retroviral replication prior to reverse transcription by downregulation of stable microtubule formation. Here, we provide evidence that overexpression of ezrin, another closely related ezrin-radixin-moesin (ERM) family member, also blocks replication of both murine leukemia viruses and human immunodeficiency virus type 1 (HIV-1) in Rat2 fibroblasts before reverse transcription, while knockdown of endogenous ezrin increases the susceptibility of human cells to HIV-1 infection. Together, these results suggest that ERM proteins may be important determinants of retrovirus susceptibility through negative regulation of stable microtubule networks.

* Corresponding author. Mailing address: Centre for Research in Infectious Diseases, University College Dublin, Belfield, Dublin 4, Ireland. Phone: 353 1 716 1223. Fax: 353 1 716 1239. E-mail: mojgan.naghavi{at}ucd.ie

{triangledown} Published ahead of print on 27 February 2008.

Journal of Virology, May 2008, p. 4665-4670, Vol. 82, No. 9
0022-538X/08/$08.00+0     doi:10.1128/JVI.02403-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

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  • Barrero-Villar, M., Cabrero, J. R., Gordon-Alonso, M., Barroso-Gonzalez, J., Alvarez-Losada, S., Munoz-Fernandez, M. A., Sanchez-Madrid, F., Valenzuela-Fernandez, A. (2009). Moesin is required for HIV-1-induced CD4-CXCR4 interaction, F-actin redistribution, membrane fusion and viral infection in lymphocytes. J. Cell Sci. 122: 103-113 [Abstract] [Full Text]  


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