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Journal of Virology, April 2008, p. 4180-4183, Vol. 82, No. 8
0022-538X/08/$08.00+0     doi:10.1128/JVI.02596-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Epstein-Barr Virus Nuclear Antigen 1 Does Not Cause Lymphoma in C57BL/6J Mice{triangledown}

Myung-Soo Kang,1 Vishal Soni,1 Roderick Bronson,2 and Elliott Kieff1*

Channing Laboratory and Infectious Diseases Division, Department of Medicine and Department of Microbiology and Molecular Genetics,1 Rodent Pathology Core, Harvard Medical School, Boston, Massachusetts 021152

Received 6 December 2007/ Accepted 25 January 2008

To test whether transgenic Epstein-Barr virus nuclear antigen 1 (EBNA1) expression in C57BL/6 mouse lymphocytes causes lymphoma, EBNA1 expressed in three FVB lineages at two or three times the level of latent infection was crossed up to six successive times into C57BL/6J mice. After five or six crosses, 14/36, (38%) EBNA1 transgenic mice, 11/31 (36%) littermate EBNA1-negative controls, and 9/25 (36%) inbred C57BL/6J mice housed in the same facility had lymphoma. These data indicate that EBNA1 does not significantly increase lymphoma prevalence in C57BL/6J mice.

* Corresponding author. Mailing address: Channing Laboratory and Infectious Diseases Division, Department of Medicine and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115. Phone: (617) 525-4252. Fax: (617) 525-4257. E-mail: ekieff{at}rics.bwh.harvard.edu

{triangledown} Published ahead of print on 6 February 2008.

Journal of Virology, April 2008, p. 4180-4183, Vol. 82, No. 8
0022-538X/08/$08.00+0     doi:10.1128/JVI.02596-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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