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Journal of Virology, April 2008, p. 4180-4183, Vol. 82, No. 8
0022-538X/08/$08.00+0 doi:10.1128/JVI.02596-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Channing Laboratory and Infectious Diseases Division, Department of Medicine and Department of Microbiology and Molecular Genetics,1 Rodent Pathology Core, Harvard Medical School, Boston, Massachusetts 021152
Received 6 December 2007/ Accepted 25 January 2008
To test whether transgenic Epstein-Barr virus nuclear antigen 1 (EBNA1) expression in C57BL/6 mouse lymphocytes causes lymphoma, EBNA1 expressed in three FVB lineages at two or three times the level of latent infection was crossed up to six successive times into C57BL/6J mice. After five or six crosses, 14/36, (38%) EBNA1 transgenic mice, 11/31 (36%) littermate EBNA1-negative controls, and 9/25 (36%) inbred C57BL/6J mice housed in the same facility had lymphoma. These data indicate that EBNA1 does not significantly increase lymphoma prevalence in C57BL/6J mice.
Published ahead of print on 6 February 2008.
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