JVI Try AEM Online
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
JVI.02596-07v1
82/8/4180    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Google Scholar
Right arrow Articles by Kang, M.-S.
Right arrow Articles by Kieff, E.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kang, M.-S.
Right arrow Articles by Kieff, E.
Journal of Virology, April 2008, p. 4180-4183, Vol. 82, No. 8
0022-538X/08/$08.00+0     doi:10.1128/JVI.02596-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Epstein-Barr Virus Nuclear Antigen 1 Does Not Cause Lymphoma in C57BL/6J Mice{triangledown}

Myung-Soo Kang,1 Vishal Soni,1 Roderick Bronson,2 and Elliott Kieff1*

Channing Laboratory and Infectious Diseases Division, Department of Medicine and Department of Microbiology and Molecular Genetics,1 Rodent Pathology Core, Harvard Medical School, Boston, Massachusetts 021152

Received 6 December 2007/ Accepted 25 January 2008

To test whether transgenic Epstein-Barr virus nuclear antigen 1 (EBNA1) expression in C57BL/6 mouse lymphocytes causes lymphoma, EBNA1 expressed in three FVB lineages at two or three times the level of latent infection was crossed up to six successive times into C57BL/6J mice. After five or six crosses, 14/36, (38%) EBNA1 transgenic mice, 11/31 (36%) littermate EBNA1-negative controls, and 9/25 (36%) inbred C57BL/6J mice housed in the same facility had lymphoma. These data indicate that EBNA1 does not significantly increase lymphoma prevalence in C57BL/6J mice.

* Corresponding author. Mailing address: Channing Laboratory and Infectious Diseases Division, Department of Medicine and Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115. Phone: (617) 525-4252. Fax: (617) 525-4257. E-mail: ekieff{at}rics.bwh.harvard.edu

{triangledown} Published ahead of print on 6 February 2008.

Journal of Virology, April 2008, p. 4180-4183, Vol. 82, No. 8
0022-538X/08/$08.00+0     doi:10.1128/JVI.02596-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
J. Bacteriol. Mol. Cell. Biol. Microbiol. Mol. Biol. Rev.
Clin. Vaccine Immunol. ALL ASM JOURNALS

Copyright © 2008 by the American Society for Microbiology. All rights reserved.