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Journal of Virology, April 2008, p. 3814-3821, Vol. 82, No. 8
0022-538X/08/$08.00+0     doi:10.1128/JVI.02507-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Differential Inhibition of Nuclear Hormone Receptor-Dependent Hepatitis B Virus Replication by the Small Heterodimer Partner{triangledown}

Claudia E. Oropeza, Lie Li, and Alan McLachlan*

Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 909 South Wolcott Avenue, Chicago, Illinois 60612

Received 22 November 2007/ Accepted 24 January 2008

The nuclear hormone receptors hepatocyte nuclear factor 4 (HNF4) and retinoid X receptor {alpha} (RXR{alpha}) plus peroxisome proliferator-activated receptor {alpha} (PPAR{alpha}) heterodimer support hepatitis B virus (HBV) pregenomic RNA synthesis and viral replication in nonhepatoma cells. Small heterodimer partner (SHP), an orphan nuclear hormone receptor lacking a DNA binding domain, inhibits nuclear hormone receptor-mediated viral transcription and replication. The inhibition of HBV replication by SHP is dependent on the presence of nuclear hormone receptors. HBV replication that is dependent on HNF4 is considerably more sensitive to SHP-mediated inhibition than RXR{alpha}/PPAR{alpha}-directed viral biosynthesis. SHP inhibition of HBV biosynthesis in HepG2 cells suggests that multiple nuclear hormone receptors mediate viral replication in this human hepatoma cell line. These observations suggest that the physiological regulation of HBV biosynthesis by SHP in the liver will depend on both the level of SHP expression and the relative contribution of HNF4 and RXR{alpha}/PPAR{alpha}, plus potentially additional nuclear hormone receptors, to HBV RNA synthesis and replication.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 909 South Wolcott Avenue, Chicago, IL 60612. Phone: (312) 355-0211. Fax: (312) 996-4890. E-mail: mclach{at}uic.edu

{triangledown} Published ahead of print on 30 January 2008.

Journal of Virology, April 2008, p. 3814-3821, Vol. 82, No. 8
0022-538X/08/$08.00+0     doi:10.1128/JVI.02507-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Ramiere, C., Scholtes, C., Diaz, O., Icard, V., Perrin-Cocon, L., Trabaud, M.-A., Lotteau, V., Andre, P. (2008). Transactivation of the Hepatitis B Virus Core Promoter by the Nuclear Receptor FXR{alpha}. J. Virol. 82: 10832-10840 [Abstract] [Full Text]  


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