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Journal of Virology, March 2008, p. 3154-3160, Vol. 82, No. 6
0022-538X/08/$08.00+0     doi:10.1128/JVI.02474-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

High Level of PD-1 Expression on Hepatitis C Virus (HCV)-Specific CD8+ and CD4+ T Cells during Acute HCV Infection, Irrespective of Clinical Outcome{triangledown}

Victoria Kasprowicz,1 Julian Schulze zur Wiesch,1,2,10 Thomas Kuntzen,1 Brian E. Nolan,1 Steven Longworth,1 Andrew Berical,1 Jenna Blum,1 Cory McMahon,1 Laura L. Reyor,1 Nahel Elias,1,3,10 William W. Kwok,4 Barbara G. McGovern,5 Gordon Freeman,6 Raymond T. Chung,7,10 Paul Klenerman,8 Lia Lewis-Ximenez,9 Bruce D. Walker,1,10 Todd M. Allen,1 Arthur Y. Kim,1 and Georg M. Lauer1*

Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, 6th Floor, Room 6001, Charlestown, Massachusetts 02129-2000,1 Med. Klinik I, Universität Hamburg, Germany,2 Transplantation Unit, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114,3 Benaroya Research Institute at Virginia Mason, Seattle, Washington,4 Lemuel Shattuck Hospital and Tufts University School of Medicine, Boston, Massachusetts,5 Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115,6 Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114,7 Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, South Parks Road, Oxford OX1 3SY, United Kingdom,8 Departmento de Virologia, Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil,9 Howard Hughes Medical Institute, Chevy Chase, Maryland,10

Received 16 November 2007/ Accepted 13 December 2007

We monitored expression of PD-1 (a mediator of T-cell exhaustion and viral persistence) on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells from blood and liver during acute and chronic infections and after the resolved infection stage. PD-1 expression on HCV-specific T cells was high early in acute infection irrespective of clinical outcome, and most cells continued to express PD-1 in resolved and chronic stages of infection; intrahepatic expression levels were especially high. Our results suggest that an analysis of PD-1 expression alone is not sufficient to predict infection outcome or to determine T-cell functionality in HCV infection.

* Corresponding author. Mailing address: Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129. Phone: (617) 724-7515. Fax: (617) 726-5411. E-mail: glauer{at}partners.org

{triangledown} Published ahead of print on 26 December 2007.

Journal of Virology, March 2008, p. 3154-3160, Vol. 82, No. 6
0022-538X/08/$08.00+0     doi:10.1128/JVI.02474-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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