This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yerly, D.
Right arrow Articles by Brander, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yerly, D.
Right arrow Articles by Brander, C.

 Previous Article  |  Next Article 

Journal of Virology, March 2008, p. 3147-3153, Vol. 82, No. 6
0022-538X/08/$08.00+0     doi:10.1128/JVI.02252-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Increased Cytotoxic T-Lymphocyte Epitope Variant Cross-Recognition and Functional Avidity Are Associated with Hepatitis C Virus Clearance{triangledown}

Daniel Yerly,1,2 David Heckerman,3 Todd M. Allen,2 John V. Chisholm III,2 Kellie Faircloth,2 Caitlyn H. Linde,2 Nicole Frahm,2 Joerg Timm,4 Werner J. Pichler,1 Andreas Cerny,5 and Christian Brander2*

University of Bern, Clinic for Rheumatology and Clinical Immunology/Allergology, CH-3010 Bern, Switzerland,1 Massachusetts General Hospital and Harvard Medical School, Partners AIDS Research Center, Boston, Massachusetts,2 Microsoft Research, Redmond, Washington 98052,3 University Hospital Essen, Institute for Virology, Essen, Germany,4 Ospedale Regionale di Lugano, Department of Medicine, CH-6903 Lugano, Switzerland5

Received 17 October 2007/ Accepted 27 December 2007

Hepatitis C virus (HCV) clearance has been associated with reduced viral evolution in targeted cytotoxic T-lymphocyte (CTL) epitopes, suggesting that HCV clearers may mount CTL responses with a superior ability to recognize epitope variants and prevent viral immune escape. Here, 40 HCV-infected subjects were tested with 406 10-mer peptides covering the vast majority of the sequence diversity spanning a 197-residue region of the NS3 protein. HCV clearers mounted significantly broader CTL responses of higher functional avidity and with wider variant cross-recognition capacity than nonclearers. These observations have important implications for vaccine approaches that may need to induce high-avidity responses in vivo.

* Corresponding author. Mailing address: Massachusetts General Hospital and Harvard Medical School, Partners AIDS Research Center, MGH East no. 5239, 149 13th St., Charlestown, MA 02143. Phone: (617) 724-5789. Fax: (617) 726-5345. E-mail: cbrander{at}partners.org

{triangledown} Published ahead of print on 9 January 2008.

Journal of Virology, March 2008, p. 3147-3153, Vol. 82, No. 6
0022-538X/08/$08.00+0     doi:10.1128/JVI.02252-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Yerly, D., Heckerman, D., Allen, T., Suscovich, T. J., Jojic, N., Kadie, C., Pichler, W. J., Cerny, A., Brander, C. (2008). Design, Expression, and Processing of Epitomized Hepatitis C Virus-Encoded CTL Epitopes. J. Immunol. 181: 6361-6370 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»