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 Previous Article

Journal of Virology, March 2008, p. 2598-2603, Vol. 82, No. 5
0022-538X/08/$08.00+0     doi:10.1128/JVI.01613-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Combination of an Antiviral Drug and Immunomodulation against Hepadnaviral Infection in the Woodchuck Model{triangledown}

Mengji Lu,1* Xin Yao,2 Yang Xu,1 Heike Lorenz,3 Uta Dahmen,4 Haidong Chi,4 Olaf Dirsch,5 Thekla Kemper,1 Lifang He,2 Dieter Glebe,3 Wolfram H. Gerlich,3 Yumei Wen,2 and Michael Roggendorf1

Institut für Virologie, Universitätsklinikum Essen, Essen, Germany,1 Department of Molecular Virology, Medical Center of Fudan University, Shanghai, People's Republic of China,2 Institut fuer Medizinische Virologie, Justus-Liebig-Universitaet Giessen, Giessen,3 Klinik für Allgemeine Viszeral- und Transplantationschirugie, Univesitaetsklinkum Essen, Essen,4 Institut fuer Pathologie, Universitaetsklinkum Köln, Cologne, Germany5

Received 24 July 2007/ Accepted 14 December 2007

The essential role of multispecific immune responses for the control of hepatitis B virus (HBV) infection implies the need of multimodal therapeutic strategies for chronic HBV infection, including antiviral chemotherapy and immunomodulation. This hypothesis was tested in the woodchuck model by a combination of lamivudine pretreatment and subsequent immunizations of woodchucks chronically infected with woodchuck hepatitis virus. The immunizations were performed with DNA vaccines or antigen-antibody immune complexes (IC)/DNA vaccines. Immunizations with IC/DNA vaccines led to an anti-woodchuck hepatitis virus surface antibody response and significant reductions of viral load and antigenemia, suggesting that such a strategy may be effective against chronic HBV infection.

* Corresponding author. Mailing address: Institut für Virologie, Universitätsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany. Phone: 49 201 723 3530. Fax: 49 201 723 5929. E-mail: mengji.lu{at}uni-due.de

{triangledown} Published ahead of print on 26 December 2007.

Journal of Virology, March 2008, p. 2598-2603, Vol. 82, No. 5
0022-538X/08/$08.00+0     doi:10.1128/JVI.01613-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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