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Journal of Virology, March 2008, p. 2586-2589, Vol. 82, No. 5
0022-538X/08/$08.00+0     doi:10.1128/JVI.02291-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Expression of Murine Leukemia Virus Envelope Protein Is Sufficient for the Induction of Apoptosis{triangledown}

Xiaoqing Zhao and Fayth K. Yoshimura*

Department of Immunology and Microbiology and the Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201

Received 22 October 2007/ Accepted 3 December 2007

The generation of cytopathic effects by murine leukemia viruses (MLVs) in different cell types correlates with the ability of the virus to induce thymic lymphoma. We showed that the induction of apoptosis in mink epithelial cells by mink cell focus-forming (MCF) MLV infection results in the accumulation of high levels of both unintegrated viral DNA and the envelope precursor polyprotein (gPr80env). Comparisons of envelope protein expression levels of plasmid clones of the env gene of the MCF13 and noncytopathic NZB-9 MLV strains demonstrated that the accumulation of MCF13 gPr80env results in endoplasmic reticulum stress and is sufficient for the induction of apoptosis.

* Corresponding author. Mailing address: Department of Immunology and Microbiology, Wayne State University, 540 E. Canfield Ave., Detroit, MI 48201. Phone: (313) 577-1571. Fax: (313) 577-1155. E-mail: fyoshi{at}med.wayne.edu

{triangledown} Published ahead of print on 12 December 2007.

Journal of Virology, March 2008, p. 2586-2589, Vol. 82, No. 5
0022-538X/08/$08.00+0     doi:10.1128/JVI.02291-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



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