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Journal of Virology, December 2008, p. 12569-12573, Vol. 82, No. 24
0022-538X/08/$08.00+0     doi:10.1128/JVI.01395-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Role of Ebola Virus VP30 in Transcription Reinitiation{triangledown}

Miguel J. Martínez,1,2,{dagger} Nadine Biedenkopf,3,4,{dagger} Valentina Volchkova,1,2,5,6 Bettina Hartlieb,3,4 Nathalie Alazard-Dany,1,2,{ddagger} Olivier Reynard,1,2 Stephan Becker,3,4* and Viktor Volchkov1,2,5,6*

INSERM, U758, Filovirus Laboratory, 21 Av. Tony Garnier, Lyon F-69007, France,1 IFR 128, Lyon F-69007, France,2 Robert-Koch-Institut, ZBS5 Berlin, Germany,3 Institut für Virologie, Philipps Universität Marburg, Marburg, Germany,4 Université de Lyon, Lyon F-69007, France,5 Université de Lyon 1, Villeurbanne F-69622, France6

Received 3 July 2008/ Accepted 19 September 2008

VP30 is a phosphoprotein essential for the initiation of Ebola virus transcription. In this work, we have studied the effect of mutations in VP30 phosphorylation sites on the ebolavirus replication cycle by using a reverse genetics system. We demonstrate that VP30 is involved in reinitiation of gene transcription and that this activity is affected by mutations at the phosphorylation sites.

* Corresponding author. Mailing address for Viktor Volchkov: INSERM, U758, Filovirus Laboratory, 21 Av. Tony Garnier, 69365 Lyon, Cedex 07, France. Phone: 33 437 282450. Fax: 33 437 282459. E-mail: viktor.volchkov{at}inserm.fr. Mailing address for Stephan Becker: Institut für Virologie, Philipps-Universität Marburg, 35037 Marburg, Germany. Phone: 49 6421 2866253. Fax: 49 6421 2868899. E-mail: becker{at}staff.uni-marburg.de

{triangledown} Published ahead of print on 1 October 2008.

{dagger} These authors contributed equally to this work.

{ddagger} Present address: INSERM, U758, Ecole Normale Supérieure, 46 allée d'Italie, 69364 Lyon, Cedex 07, France.

Journal of Virology, December 2008, p. 12569-12573, Vol. 82, No. 24
0022-538X/08/$08.00+0     doi:10.1128/JVI.01395-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Enterlein, S., Schmidt, K. M., Schumann, M., Conrad, D., Krahling, V., Olejnik, J., Muhlberger, E. (2009). The Marburg Virus 3' Noncoding Region Structurally and Functionally Differs from That of Ebola Virus. J. Virol. 83: 4508-4519 [Abstract] [Full Text]  


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