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Journal of Virology, December 2008, p. 11992-11996, Vol. 82, No. 23
0022-538X/08/$08.00+0     doi:10.1128/JVI.01094-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Utilization of DC-SIGN for Entry of Feline Coronaviruses into Host Cells{triangledown}

Andrew D. Regan1,2 and Gary R. Whittaker1*

Department of Microbiology and Immunology,1 Graduate Field of Microbiology, College of Veterinary Medicine, Cornell University, Ithaca, New York 148532

Received 23 May 2008/ Accepted 8 September 2008

The entry and dissemination of viruses in several families can be mediated by C-type lectins such as DC-SIGN. We showed that entry of the serotype II feline coronavirus strains feline infectious peritonitis virus (FIPV) WSU 79-1146 and DF2 into nonpermissive mouse 3T3 cells can be rescued by the expression of human DC-SIGN (hDC-SIGN) and that infection of a permissive feline cell line (Crandall-Reese feline kidney) was markedly enhanced by the overexpression of hDC-SIGN. Treatment with mannan considerably reduced infection of feline monocyte-derived cells expressing DC-SIGN, indicating a role for FIPV infection in vivo.

* Corresponding author. Mailing address: C4127 Veterinary Medical Center, Dept. of Microbiology and Immunology, Cornell University, Ithaca, NY 14853. Phone: (607) 253-4019. Fax: (607) 253-3385. E-mail: grw7{at}cornell.edu

{triangledown} Published ahead of print on 17 September 2008.

Journal of Virology, December 2008, p. 11992-11996, Vol. 82, No. 23
0022-538X/08/$08.00+0     doi:10.1128/JVI.01094-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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