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Journal of Virology, December 2008, p. 11970-11975, Vol. 82, No. 23
0022-538X/08/$08.00+0     doi:10.1128/JVI.01053-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Primary Clearance of Murine Gammaherpesvirus 68 by PKC{theta}–/– CD8 T Cells Is Compromised in the Absence of Help from CD4 T Cells{triangledown}

Peter Dias, Ashley L. Shea,{dagger} Chandra Inglis,{ddagger} Francesca Giannoni,§ Lian Ni Lee, and Sally R. Sarawar*

Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, California 92121

Received 20 May 2008/ Accepted 16 September 2008

CD4 T cells are dispensable for acute control of murine gammaherpesvirus 68 (MHV-68) but are necessary for effective long-term control of the virus by CD8 T cells. In contrast, protein kinase C {theta} (PKC{theta}) is not essential for either acute or long-term viral control. However, we found that while either CD4 or CD8 T cells could mediate the clearance of MHV-68 from the lungs of PKC{theta}+/+ mice, PKC{theta}–/– mice depleted of either subset failed to clear the virus. These data suggest that there are two alternative pathways for MHV-68 clearance, one dependent on CD4 T cells and the other on PKC{theta}. Protection mediated by the latter appears to be short-lived. These observations may help to explain the differential requirement for PKC{theta} in various models of CD8 T-cell activation and differences in the costimulatory requirements for acute and long-term viral control.

* Corresponding author. Mailing address: Viral Immunology, Torrey Pines Institute for Molecular Studies, 3550 General Atomics Court, San Diego, CA 92121. Phone: (858) 909-5139. Fax: (858) 909-5141. E-mail: ssarawar{at}tpims.org

{triangledown} Published ahead of print on 25 September 2008.

{dagger} Present address: Novartis, 500 Technology Square, Cambridge, MA 02139.

{ddagger} Present address: Department of Neuroscience, UCSD, 9500 Gilman Drive # 0624, La Jolla, CA 92093-0624.

§ Present address: Division of Research Immunology and Bone Marrow Transplantation, CHLA, 4650 Sunset Blvd, Los Angeles, CA 90027.

Journal of Virology, December 2008, p. 11970-11975, Vol. 82, No. 23
0022-538X/08/$08.00+0     doi:10.1128/JVI.01053-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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