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Journal of Virology, November 2008, p. 10953-10958, Vol. 82, No. 21
0022-538X/08/$08.00+0     doi:10.1128/JVI.01312-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Genetically Divergent Strains of Feline Immunodeficiency Virus from the Domestic Cat (Felis catus) and the African Lion (Panthera leo) Share Usage of CD134 and CXCR4 as Entry Receptors{triangledown}

William A. McEwan,1 Elizabeth L. McMonagle,1 Nicola Logan,1 Rodrigo C. Serra,2 Pieter Kat,2 Sue VandeWoude,3 Margaret J. Hosie,1 and Brian J. Willett1*

Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom,1 Investigação Veterinária Independente, R. Constantino Fernandes, 20 3Fte, 1700-119 Lisbon, Portugal,2 Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biological Sciences, Colorado State University, Fort Collins, Colorado 805233

Received 24 June 2008/ Accepted 11 August 2008

The env open reading frames of African lion (Panthera leo) lentivirus (feline immunodeficiency virus [FIVPle]) subtypes B and E from geographically distinct regions of Africa suggest two distinct ancestries, with FIVPle-E sharing a common ancestor with the domestic cat (Felis catus) lentivirus (FIVFca). Here we demonstrate that FIVPle-E and FIVFca share the use of CD134 (OX40) and CXCR4 as a primary receptor and coreceptor, respectively, and that both lion CD134 and CXCR4 are functional receptors for FIVPle-E. The shared usage of CD134 and CXCR4 by FIVFca and FIVPle-E may have implications for in vivo cell tropism and the pathogenicity of the E subtype among free-ranging lion populations.

* Corresponding author. Mailing address: Retrovirus Research Laboratory, Institute of Comparative Medicine, Faculty of Veterinary Medicine, University of Glasgow, Bearsden Road, Glasgow G61 1QH, United Kingdom. Phone: 44 141 330 3274. Fax: 44 141 330 2271. E-mail: b.willett{at}vet.gla.ac.uk

{triangledown} Published ahead of print on 20 August 2008.

Journal of Virology, November 2008, p. 10953-10958, Vol. 82, No. 21
0022-538X/08/$08.00+0     doi:10.1128/JVI.01312-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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