This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lorusso, A.
Right arrow Articles by de Groot, R. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lorusso, A.
Right arrow Articles by de Groot, R. J.

 Previous Article  |  Next Article 

Journal of Virology, October 2008, p. 10312-10317, Vol. 82, No. 20
0022-538X/08/$08.00+0     doi:10.1128/JVI.01031-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Gain, Preservation, and Loss of a Group 1a Coronavirus Accessory Glycoprotein{triangledown}

Alessio Lorusso,1,2 Nicola Decaro,2 Pepijn Schellen,1 Peter J. M. Rottier,1 Canio Buonavoglia,2 Bert-Jan Haijema,1 and Raoul J. de Groot1*

Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands,1 Department of Public Health and Zootechnics, Faculty of Veterinary Medicine of Bari, Bari, Italy2

Received 16 May 2008/ Accepted 21 July 2008

Coronaviruses are positive-strand RNA viruses of extraordinary genetic complexity and diversity. In addition to a common set of genes for replicase and structural proteins, each coronavirus may carry multiple group-specific genes apparently acquired through relatively recent heterologous recombination events. Here we describe an accessory gene, ORF3, unique to canine coronavirus type I (CCoV-I) and characterize its product, glycoprotein gp3. Whereas ORF3 is conserved in CCoV-I, only remnants remain in CCoV-II and CCoV-II-derived porcine and feline coronaviruses. Our findings provide insight into the evolutionary history of coronavirus group 1a and into the dynamics of gain and loss of accessory genes.

* Corresponding author. Mailing address: Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584 CL Utrecht, The Netherlands. Phone: 31 30 2531463. Fax: 31 30 2536723. E-mail: r.j.degroot{at}uu.nl

{triangledown} Published ahead of print on 30 July 2008.

Journal of Virology, October 2008, p. 10312-10317, Vol. 82, No. 20
0022-538X/08/$08.00+0     doi:10.1128/JVI.01031-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Decaro, N., Mari, V., Campolo, M., Lorusso, A., Camero, M., Elia, G., Martella, V., Cordioli, P., Enjuanes, L., Buonavoglia, C. (2009). Recombinant Canine Coronaviruses Related to Transmissible Gastroenteritis Virus of Swine Are Circulating in Dogs. J. Virol. 83: 1532-1537 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»