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Journal of Virology, October 2008, p. 10290-10294, Vol. 82, No. 20
0022-538X/08/$08.00+0     doi:10.1128/JVI.00882-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Adenovirus IVa2 Protein Binds ATP{triangledown}

Philomena Ostapchuk and Patrick Hearing*

Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, New York 11794

Received 25 April 2008/ Accepted 22 July 2008

IVa2 is an essential, multifunctional protein of adenovirus (Ad) supporting packaging of the viral genome into the capsid, assisting in assembly of the capsid, and activating Ad late transcription. A comparison of IVa2 protein sequences from different species of Adenoviridae shows conserved motifs associated with binding and hydrolysis of ATP (Walker A and B motifs). ATPases are essential proteins of bacteriophage packaging motors, and such activity may be required for Ad packaging. Results presented here show that the Ad2 IVa2 protein binds ATP in vitro and that sequences in the Walker A and B motifs are necessary for this activity.

* Corresponding author. Mailing address: Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11794. Phone: (631) 632-8813. Fax: (631) 632-8891. E-mail: phearing{at}ms.cc.sunysb.edu

{triangledown} Published ahead of print on 30 July 2008.

Journal of Virology, October 2008, p. 10290-10294, Vol. 82, No. 20
0022-538X/08/$08.00+0     doi:10.1128/JVI.00882-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Russell, W. C. (2009). Adenoviruses: update on structure and function. J. Gen. Virol. 90: 1-20 [Abstract] [Full Text]  


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