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Journal of Virology, January 2008, p. 1034-1039, Vol. 82, No. 2
0022-538X/08/$08.00+0     doi:10.1128/JVI.01426-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Murine Gammaherpesvirus 68 Genes both Induce and Suppress Lymphoproliferative Disease{triangledown}

Vera L. Tarakanova,1,{dagger} Friederike Kreisel,1,{dagger} Douglas W. White,1,2 and Herbert W. Virgin IV1,3*

Department of Pathology and Immunology,1 Department of Internal Medicine, Division of Rheumatology,2 Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri 631103

Received 29 June 2007/ Accepted 23 October 2007

Gammaherpesvirus infection is associated with an increased incidence of lymphoproliferative disease in immunocompromised hosts. Murine gammaherpesvirus 68 ({gamma}HV68) infection of BALB β2-microglobulin-deficient (BALB β2m–/–) mice provides an animal model for analysis of the mechanisms responsible for the induction of a lymphoproliferative disease, atypical lymphoid hyperplasia (ALH), that is pathologically similar to posttransplant lymphoproliferative disease associated with Epstein-Barr virus infection. Here we report that the {gamma}HV68 v-cyclin and v-bcl-2 genes are required for the efficient induction of {gamma}HV68-associated ALH in BALB β2m–/– mice, while the v-GPCR gene is dispensable for ALH induction. In contrast to these findings, deletion of the viral M1 gene enhanced ALH. Thus, {gamma}HV68 genes can either inhibit or enhance the induction of lymphoproliferative disease in immunocompromised mice.

* Corresponding author. Mailing address: Department of Pathology and Immunology, Washington University, 660 S. Euclid Ave, Box 8118, St. Louis, MO 63110. Phone: (314) 362-9223. Fax: (314) 362-0369. E-mail: virgin{at}wustl.edu

{triangledown} Published ahead of print on 31 October 2007.

{dagger} V.L.T. and F.K. contributed equally to this study.

Journal of Virology, January 2008, p. 1034-1039, Vol. 82, No. 2
0022-538X/08/$08.00+0     doi:10.1128/JVI.01426-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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