This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shin, E.-C.
Right arrow Articles by Rehermann, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shin, E.-C.
Right arrow Articles by Rehermann, B.

 Previous Article  |  Next Article 

Journal of Virology, October 2008, p. 9782-9788, Vol. 82, No. 19
0022-538X/08/$08.00+0     doi:10.1128/JVI.00475-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

The Kinetics of Hepatitis C Virus-Specific CD8 T-Cell Responses in the Blood Mirror Those in the Liver in Acute Hepatitis C Virus Infection{triangledown}

Eui-Cheol Shin,1,{dagger},{ddagger} Stefania Capone,2,{ddagger} Riccardo Cortese,2 Stefano Colloca,2 Alfredo Nicosia,2 Antonella Folgori,2 and Barbara Rehermann1*

Immunology Section, Liver Diseases Branch, NIDDK, National Institutes of Health, DHHS, Bethesda, Maryland 20892,1 Okairos, Naples, Italy2

Received 4 March 2008/ Accepted 21 July 2008

Peripheral blood T-cell responses are used as biomarkers in hepatitis C virus (HCV) vaccine trials. However, it is not clear how T-cell responses in the blood correlate with those in the liver, the infection site. By studying serial liver and blood samples of five vaccinated and five mock-vaccinated control chimpanzees during acute HCV infection, we demonstrate a correlation between HCV-specific CD8 T-cell responses in the blood and molecular and functional markers of T-cell responses in the liver. Thus, HCV-specific CD8 T-cell responses in the blood are valid markers for intrahepatic T-cell activity.

* Corresponding author. Mailing address: Immunology Section, LDB, NIDDK, NIH, Bethesda, MD 20892-1800. Phone: (301) 402-7144. Fax: (301) 402-0491. E-mail: Rehermann{at}nih.gov

{triangledown} Published ahead of print on 30 July 2008.

{dagger} Present address: Graduate School of Medical Science and Engineering, KAIST, Daejeon, Republic of Korea.

{ddagger} Equal contribution.

Journal of Virology, October 2008, p. 9782-9788, Vol. 82, No. 19
0022-538X/08/$08.00+0     doi:10.1128/JVI.00475-08
Copyright © 2008, American Society for Microbiology. All Rights Reserved.



This article has been cited by other articles:

  • Chang, D.-Y., Shin, E.-C. (2009). Immune-based therapy for chronic hepatitis C. J. Leukoc. Biol. 86: 33-39 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»